0178 2B-Alert App: Personalized Caffeine Recommendations for Optimal Alertness

Abstract Introduction Sleep loss causes millions of individuals around the world to carry out daily activities with impaired alertness, affecting injury risk and productivity. If properly consumed, caffeine can safely effectively mitigate effects sleep on alertness. However, be effective, should consumed at right time in correct amount, depending history, work schedule and, importantly, sensitivity loss. Here, we present 2B-Alert app, a unique smartphone application capabilities learn an individual’s trait-like response provide personalized recommendations optimize Methods We conducted prospective 62-h total deprivation study validate 2B-Alert. Throughout challenge, 21 participants used app measure their alertness via psychomotor vigilance test (PVT). The PVT data collected during first 36 h wakefulness each participant’s sleep-loss provided on-the-fly (from 0 800 mg), so that participant would sustain pre-specified target level (mean 270 ms) 6-h period starting 44 into challenge. To assess effectiveness recommendations, computed amount fell within +/-2 times within-subject variability impairment (i.e., +/-60 ms). Results observed wide range responses loss, some displaying high levels resilience others vulnerability. Accordingly, recommended no five participants, 100-400 mg 11 500-800 participants. Regardless caffeine, sustained ~80% period. Conclusion automatically learns provides real achieve desired regardless susceptibility Support (if any)